Input effects on the acquisition of a novel phrasal construction in five year olds

The present experiments demonstrate that children as young as five years old (M = 5;2) generalize beyond their input on the basis of minimal exposure to a novel argument structure construction. The novel construction that was used involved a non-English phrasal pattern: VN1N2, paired with a novel abstract meaning: N2 approaches N1. At the same time, we find that children are keenly sensitive to the input: they show knowledge of the construction after a single day of exposure but this grows stronger after three days; also, children generalize more readily to new verbs when the input contains more than one verb

Community-Based Trials of Mobile Solutions for the Detection and Management of Cognitive Decline

This study focused on the development and usability evaluation of EnCare diagnostics (ECD) and the brain fit plan (BFP) in healthy older adults, cognitively impaired and physically impaired individuals. ECD is proposed as a novel solution to cognitive assessment based on colour selection. BFP is a novel solution to personalised cognitive stimulation. The study consisted of two trials designed to evaluate the usability of the apps. Trial 1 involved 11 healthy older adults and four older adults with physical impairments who undertook ECD and mini-mental state examination (MMSE) once per month for 4 months with only those with physical impairments also completing the BFP daily. Trial 2 involved eight older adults diagnosed with early stage dementia who completed MMSE and ECD once per month for 6 months. In Trial 1, 10 out of 11 participants enjoyed the trial and managed the usability of the app easily. A 75% drop out was observed in response to the BFP with issues of dexterity and lack of understanding on how to use the technology being the main reasons for lack of compliance. Four out of eight participants completed Trial 2 with most of the participants having no usability issues. This usability study demonstrated that ECD is highly acceptable in both healthy older adults and those with early stage dementia when given the shorter versions to accommodate their diagnosis. The BFP was not suited to this population of participants

Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo

Interest in nuclear imaging of poly(ADP-ribose) polymerase-1 (PARP-1) has grown in recent years due to the ability of PARP-1 to act as a biomarker for glioblastoma and increased clinical use of PARP-1 inhibitors. This study reports the identification of a lead iodinated analog 5 of the clinical PARP-1 inhibitor olaparib as a potential single-photon emission computed tomography (SPECT) imaging agent. Compound 5 was shown to be a potent PARP-1 inhibitor in cell-free and cellular assays, and it exhibited mouse plasma stability but approximately 3-fold greater intrinsic clearance when compared to olaparib. An (123)I-labeled version of 5 was generated using solid state halogen exchange methodology. Ex vivo biodistribution studies of [(123)I]-5 in mice bearing subcutaneous glioblastoma xenografts revealed that the tracer had the ability to be retained in tumour tissue and bind to PARP-1 with specificity. These findings support further investigations of [(123)I]-5 as a non-invasive PARP-1 SPECT imaging agent

MMIC Amplifiers for 90 to 130 GHz

This brief describes two monolithic microwave integrated-circuit (MMIC) amplifier chips optimized to function in the frequency range of 90 to 130 GHz, covering nearly all of F-band (90 - 140 GHz). These amplifiers were designed specifically for local-oscillator units in astronomical radio telescopes such as the Atacama Large Millimeter Array (ALMA). They could also be readily adapted for use in electronic test equipment, automotive radar systems, and communications systems that operate between 90 and 130 GHz

The Grizzly, November 13, 1987

Moon Shines Over Quad • Curriculum to Change • Zimmer Aids Evaluation • Letters: Team Demands Action; Kane Addresses Social Problems; Director Apologizes to Team • Professor to Publish Book • Interns: Opportunities to Enhance Learning • Apartheid Subject of Forum • New Room Policy Instituted • Speaker to Dissect Pediatrics • Irish Brandy Top Ten • Sun Your Buns Spring Break • Coffeehouses Not Thing of the Past • No Good Will From Those Ambassadorshttps://digitalcommons.ursinus.edu/grizzlynews/1199/thumbnail.jp

Cold temperature does not affect perceived exertion in males and females during submaximal cycling

Background: Perceived exertion is an acknowledged indicator of exercise intensity and homeostasis disturbance of an individual, however, there are few studies that have examined the influence of cold temperatures on perceived exertion measurements. Cognition is crucial to perception and exposure to cold temperatures can elicit decrements in cognition. Aims & Objectives: The aim of this study was to determine if, and to what extent, exposure to cold environments may influence perceived exertion and cognitive ability. Study Design: Randomised controlled trial. Materials & Methods: Sixteen participants (m= 8, f= 8, age: 22.3 ± 1.7 years (mean ± SD)), completed two trials in a randomised order in COLD (5°C) and CONTROL (18 °C, 55% relative humidity) conditions. During each trial, following a standardised warm up, participants performed a 6-minute cycle ergometer submaximal exercise. Cognitive ability was assessed pre and post exercise with a reaction time (RT) test. Participant’s physiological responses were measured using Rate of Perceived Exertion (RPE), Heart Rate (HR), Oxygen consumption (VO2), Minute Ventilation (VE), Tympanic (Tt) and Skin Temperature (Tsk) continuously during testing. Statistics: Two-way repeated measures Analysis of Variances (ANOVA), were between environmental conditions over time.Data are reported as mean (M) ± standard deviation (SD).Ordinal Friedman ANOVA tests were conducted on RPE data between environmental conditions and gender. Non-parametric descriptive statistics were reported as medians (Mdn) and inter-quartile ranges (IQR) (25th–75thPercentile). Statistical significance was accepted at p 0.05) reported in RPE, VO2 and VEbetween COLD and CONTROL groups, however, significant decreases in Tsk(p= 0.001) and Tt(p= 0.001) were observed in COLD compared to CONTROL groups. Additionally, no significant differences (p > 0.05) in RT occurred between COLD and CONTROL. Furthermore, no significant differences in RPE were established between genders. Conclusions: Short-term exposure to cold temperatures does not significantly affect physical exertion perception or cognitive abilit